Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28923042 | 1.00 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DJAK2 | |
| SCHEMBL6364579 | 0.89 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DJAK2 | |
| SCHEMBL387446 | 0.83 | — | — | |
| SCHEMBL194209 | 0.83 | — | — | |
| SCHEMBL28941207 | 0.82 | STS (0.40) | JAK2JAK1STSOPRD1OPRK1 | |
| SCHEMBL28625824 | 0.82 | — | — | |
| SCHEMBL28632434 | 0.79 | STS (0.42) | PDE4APDE4BPDE4CPDE4DJAK2 | |
| SCHEMBL30882363 | 0.79 | JAK2 (0.39) | JAK2JAK1STSUSP30GPR119 | |
| SCHEMBL11953974 | 0.77 | — | — | |
| SCHEMBL968202 | 0.77 | STS (0.39) | PDE4APDE4BPDE4CPDE4DSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113395996-B | Arginase inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-114599372-A | Combination therapy for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-113395996-A | Arginase inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-14 | — | — | CN | disclosed |