Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856662 | 0.84 | SRC (0.32) | NT5ESRCP2RX7 | |
| SCHEMBL2864508 | 0.78 | JAK2 (0.45) | — | |
| SCHEMBL2868692 | 0.76 | MAPT (0.36) | — | |
| SCHEMBL2858032 | 0.71 | JAK2 (0.44) | NT5E | |
| SCHEMBL13931055 | 0.67 | JAK2 (0.47) | — | |
| SCHEMBL3502468 | 0.61 | JAK2 (0.44) | — | |
| SCHEMBL2865692 | 0.59 | JAK2 (0.46) | — | |
| SCHEMBL604108 | 0.57 | TSHR (0.50) | — | |
| SCHEMBL13930511 | 0.57 | JAK2 (0.46) | — | |
| SCHEMBL29758344 | 0.57 | MTOR (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |