Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 5/20 | 0.57 |
| ▸ | CACNG8 | Q8WXS5 | 4/20 | 0.57 |
| ▸ | PGR | P06401 | 4/20 | 0.54 |
| ▸ | AHR | P35869 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 3/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189492 | 0.89 | GRIA1 (0.61) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL18189520 | 0.87 | GRIA1 (0.65) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL18189567 | 0.86 | GRIA1 (0.55) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL18189478 | 0.86 | PDE3B (0.65) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL18189570 | 0.85 | GRIA1 (0.73) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL18189648 | 0.82 | GRIA1 (0.56) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL18189645 | 0.81 | GRIA1 (0.57) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL18189652 | 0.81 | CYP11B1 (0.68) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL18189531 | 0.80 | GRIA1 (0.56) | GRIA1CACNG8PGRAHRPDE3B | |
| SCHEMBL18189565 | 0.79 | GRIA1 (0.55) | GRIA1CACNG8PGRAHRPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107750250-B | Indolone compounds and their use as AMPA receptor modulators | 詹森药业有限公司 | 2021-09-07 | — | — | CN | disclosed |