Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871609 | 0.88 | JAK2 (0.64) | JAK2 | |
| SCHEMBL2865384 | 0.85 | CCNC (0.48) | JAK2CHEK1 | |
| SCHEMBL2862231 | 0.82 | JAK2 (0.59) | JAK2 | |
| SCHEMBL2871516 | 0.79 | HTT (0.53) | JAK2RXFP1 | |
| SCHEMBL2867156 | 0.78 | JAK2 (0.77) | JAK2 | |
| SCHEMBL3502725 | 0.78 | JAK2 (0.44) | JAK2 | |
| SCHEMBL3503289 | 0.78 | JAK2 (0.44) | JAK2 | |
| SCHEMBL3502356 | 0.78 | JAK2 (0.44) | JAK2 | |
| SCHEMBL2866967 | 0.78 | JAK2 (0.56) | JAK2 | |
| SCHEMBL2870458 | 0.75 | JAK2 (0.70) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | claimed |