SCHEMBL28637847

SCHEMBL28637847

O=C(O)c1ccc(CN2CCCCc3ccc(Cl)cc32)cc1

nearest known ligand 0.76

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 18/20 0.76
HDAC6 Q9UBN7 18/20 0.76
HDAC8 Q9BY41 6/20 0.62
HDAC3 O15379 3/20 0.62
HDAC2 Q92769 3/20 0.62
HDAC4 P56524 2/20 0.62
HDAC7 Q8WUI4 2/20 0.62
HDAC11 Q96DB2 2/20 0.62
HDAC9 Q9UKV0 2/20 0.62
HDAC5 Q9UQL6 2/20 0.62
HDAC10 Q969S8 1/20 0.62
NCOR2 Q9Y618 1/20 0.62
ACHE P22303 1/20 0.53
CYP2C19 P33261 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30052657 0.86 HDAC1 (1.00) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL23950389 0.86 HDAC1 (1.00) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL23950244 0.85 HDAC1 (0.73) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL17502340 0.81 HDAC1 (0.76) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL28635779 0.79 HDAC1 (0.78) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL20548117 0.79 HDAC6 (0.86) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL6225227 0.78 HDAC1 (0.53) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL30767618 0.78 TRPV1 (0.56) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL25058871 0.77 HDAC1 (1.00) HDAC1HDAC6HDAC8HDAC3HDAC2
SCHEMBL19260278 0.77 HDAC1 (1.00) HDAC1HDAC6HDAC8HDAC3HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113527206-B Benzoazaheterocycle compound, preparation method and application thereof 上海中泽医药科技有限公司 2022-12-30 CN disclosed
CN-113527206-A Benzoazaheterocycle compound, preparation method and application thereof 上海中泽医药科技有限公司 2021-10-22 CN disclosed