Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.77 |
| ▸ | SYK | P43405 | 2/20 | 0.72 |
| ▸ | BRD4 | O60885 | 3/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.65 |
| ▸ | AURKA | O14965 | 2/20 | 0.65 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.65 |
| ▸ | PAK4 | O96013 | 2/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.65 |
| ▸ | LCK | P06239 | 2/20 | 0.65 |
| ▸ | FYN | P06241 | 2/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | RET | P07949 | 2/20 | 0.65 |
| ▸ | IGF1R | P08069 | 2/20 | 0.65 |
| ▸ | MET | P08581 | 2/20 | 0.65 |
| ▸ | PRKACA | P17612 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26072888 | 0.88 | EGFR (0.70) | EGFRFGFR1SYKBRD4PDGFRA | |
| SCHEMBL29793973 | 0.86 | PDGFRA (0.85) | EGFRFGFR1BRD4PDGFRAPDGFRB | |
| SCHEMBL24625523 | 0.86 | PDGFRB (0.83) | EGFRFGFR1BRD4PDGFRAPDGFRB | |
| SCHEMBL26394690 | 0.86 | PDGFRA (0.85) | EGFRFGFR1BRD4PDGFRAPDGFRB | |
| SCHEMBL29793826 | 0.85 | EGFR (0.79) | EGFRFGFR1SYKBRD4PDGFRA | |
| SCHEMBL26394684 | 0.85 | EGFR (0.79) | EGFRFGFR1SYKBRD4PDGFRA | |
| SCHEMBL26394706 | 0.84 | EGFR (0.77) | EGFRFGFR1BRD4PDGFRAPDGFRB | |
| SCHEMBL736542 | 0.83 | SYK (1.00) | EGFRFGFR1SYK | |
| SCHEMBL763394 | 0.83 | SYK (0.87) | EGFRFGFR1SYKPDGFRAPDGFRB | |
| SCHEMBL24625519 | 0.83 | EGFR (0.75) | EGFRFGFR1SYKBRD4PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112778282-B | Pyrimidine micromolecule compound and application thereof | 温州医科大学 | 2022-07-22 | — | — | CN | disclosed |
| CN-112778282-A | Pyrimidine micromolecule compound and application thereof | 温州医科大学 | 2021-05-11 | — | — | CN | disclosed |