Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 15/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28639429 | 1.00 | NTRK1 (0.45) | NTRK1JAK2CCNT1CDK9NTRK3 | |
| SCHEMBL28663932 | 0.84 | MAPT (0.52) | NTRK1JAK2CCNT1CDK9NTRK3 | |
| SCHEMBL28663933 | 0.84 | MAPT (0.52) | NTRK1JAK2CCNT1CDK9NTRK3 | |
| SCHEMBL23000159 | 0.77 | NTRK1 (0.48) | NTRK1JAK2NTRK3 | |
| SCHEMBL21494234 | 0.77 | NTRK1 (0.48) | NTRK1JAK2NTRK3 | |
| SCHEMBL16310706 | 0.75 | SLC6A2 (0.44) | — | |
| SCHEMBL19547181 | 0.75 | NTRK1 (0.49) | NTRK1JAK2 | |
| SCHEMBL29746839 | 0.74 | NTRK1 (0.47) | NTRK1JAK2NTRK3 | |
| SCHEMBL10241011 | 0.73 | CCNT1 (0.52) | CCNT1CDK9 | |
| SCHEMBL21494188 | 0.73 | NTRK1 (0.48) | NTRK1JAK2NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110386945-B | Macrocyclic kinase inhibitor | 广州白云山医药集团股份有限公司白云山制药总厂 | 2021-09-28 | — | — | CN | disclosed |