Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.48 |
| ▸ | BRAF | P15056 | 8/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22190823 | 1.00 | ERN1 (0.48) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL28640242 | 1.00 | ERN1 (0.48) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL28642487 | 1.00 | ERN1 (0.48) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL22190989 | 1.00 | ERN1 (0.48) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL22200806 | 0.92 | ERN1 (0.47) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL22191505 | 0.92 | ERN1 (0.47) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL22190820 | 0.92 | ERN1 (0.47) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL22191070 | 0.92 | ERN1 (0.47) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL22190822 | 0.92 | ERN1 (0.47) | ERN1BRAFMAPK14CCNE1CDK2 | |
| SCHEMBL29356184 | 0.92 | ERN1 (0.47) | ERN1BRAFMAPK14CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113508115-A | Pyridopyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme I (IRE I A) for the treatment of cancer diseases | 基因泰克公司 | 2021-10-15 | — | — | CN | disclosed |