SCHEMBL28645168

SCHEMBL28645168

OCc1ccccc1-n1cc(-c2ccc(Br)cc2)nn1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.51
MEN1 O00255 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
KMT2A Q03164 1/20 0.46
MIF P14174 1/20 0.45
NOTUM Q6P988 4/20 0.43
ABCG2 Q9UNQ0 2/20 0.42
ABCB1 P08183 1/20 0.42
HSD17B1 P14061 1/20 0.42
HSD17B2 P37059 1/20 0.42
DRD2 P14416 1/20 0.41
DRD4 P21917 1/20 0.41
DRD3 P35462 1/20 0.41
LDHA P00338 1/20 0.39
HDAC3 O15379 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC8 Q9BY41 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28661839 0.88 BCHE (0.65) BCHEMIFNOTUMABCG2ABCB1
SCHEMBL28644691 0.87 BCHE (0.56) BCHEMIFNOTUMABCG2ABCB1
SCHEMBL28645410 0.86 BCHE (0.51) BCHEMEN1NPC1RAB9AKMT2A
SCHEMBL28927757 0.86 BCHE (0.51) BCHEMIFNOTUMABCG2ABCB1
SCHEMBL28664377 0.85 BCHE (0.48) BCHENPC1RAB9AMIFNOTUM
SCHEMBL28116025 0.81 BCHE (0.54) BCHENPC1RAB9AMIFABCG2
SCHEMBL28661844 0.81 NOTUM (0.43) BCHENOTUMFLT3GSK3BLMNA
SCHEMBL28639709 0.78 BCHE (0.46) BCHEMIFNOTUMABCG2ABCB1
SCHEMBL28650367 0.78 BCHE (0.52) BCHENOTUMABCG2ABCB1HSD17B1
SCHEMBL28642690 0.78 MIF (0.56) BCHEMIFABCG2ABCB1DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110423239-B 1, 3-oxazine 1,2, 3-triazole derivative and synthetic method and application thereof 昆明理工大学 2021-10-26 CN claimed
CN-110423239-B 1, 3-oxazine 1,2, 3-triazole derivative and synthetic method and application thereof 昆明理工大学 2021-10-26 CN disclosed