Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 19/20 | 0.43 |
| ▸ | BRAF | P15056 | 7/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29427236 | 0.88 | RAF1 (0.54) | RAF1BRAFKCNH2 | |
| SCHEMBL16035424 | 0.88 | RAF1 (0.54) | RAF1BRAFKCNH2 | |
| SCHEMBL28635697 | 0.88 | RAF1 (0.51) | RAF1BRAF | |
| SCHEMBL22612810 | 0.82 | RAF1 (0.45) | RAF1BRAF | |
| SCHEMBL30377969 | 0.82 | RAF1 (0.45) | RAF1BRAF | |
| SCHEMBL25984083 | 0.81 | RAF1 (0.54) | RAF1BRAF | |
| SCHEMBL18988986 | 0.81 | RAF1 (0.55) | RAF1BRAF | |
| SCHEMBL30439966 | 0.81 | RAF1 (0.55) | RAF1BRAF | |
| SCHEMBL24318073 | 0.80 | RAF1 (0.51) | RAF1BRAF | |
| SCHEMBL22612768 | 0.79 | RAF1 (0.43) | RAF1BRAFKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113264945-A | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-08-17 | — | — | CN | disclosed |