Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 13/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.53 |
| ▸ | KIT | P10721 | 4/20 | 0.53 |
| ▸ | RET | P07949 | 3/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.53 |
| ▸ | FLT1 | P17948 | 3/20 | 0.53 |
| ▸ | FLT4 | P35916 | 3/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.53 |
| ▸ | STK10 | O94804 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.53 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.53 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.53 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28630533 | 0.92 | KDR (0.53) | KDRPDGFRAPDGFRBKITRET | |
| SCHEMBL28265725 | 0.86 | KDR (0.52) | KDRPDGFRAPDGFRBKITRET | |
| SCHEMBL28432824 | 0.84 | PDGFRA (0.61) | KDRPDGFRAPDGFRBKITRET | |
| SCHEMBL30785072 | 0.83 | KDR (0.66) | KDRPDGFRAPDGFRBKITRET | |
| SCHEMBL28630537 | 0.83 | KDR (0.66) | KDRPDGFRAPDGFRBKITRET | |
| SCHEMBL28429528 | 0.83 | KDR (0.50) | KDRPDGFRAPDGFRBKITRET | |
| SCHEMBL23831123 | 0.82 | FGFR4 (0.79) | KDRPDGFRAPDGFRBKITRET | |
| SCHEMBL28831506 | 0.81 | KDR (0.53) | KDRPDGFRAPDGFRBKITRET | |
| SCHEMBL14540581 | 0.80 | FGFR2 (0.53) | KDRPDGFRAPDGFRBFGFR2MET | |
| SCHEMBL28423739 | 0.80 | KDR (0.66) | KDRPDGFRAPDGFRBKITRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113307767-A | Synthetic method of lenvatinib | 山东汇海医药化工有限公司 | 2021-08-27 | — | — | CN | disclosed |
| CN-113307767-A | Synthetic method of lenvatinib | 山东汇海医药化工有限公司 | 2021-08-27 | — | — | CN | disclosed |