Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.59 |
| ▸ | LCK | P06239 | 18/20 | 0.59 |
| ▸ | BTK | Q06187 | 4/20 | 0.59 |
| ▸ | EGFR | P00533 | 11/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29931205 | 1.00 | JAK3 (0.59) | JAK3LCKBTKEGFR | |
| SCHEMBL30160837 | 0.90 | JAK3 (0.51) | JAK3LCKBTKEGFR | |
| SCHEMBL30161265 | 0.87 | JAK3 (0.46) | JAK3LCKBTKEGFR | |
| SCHEMBL30160707 | 0.86 | JAK3 (0.47) | JAK3LCKBTKEGFR | |
| SCHEMBL30161234 | 0.85 | LCK (0.45) | JAK3LCKBTKEGFR | |
| SCHEMBL30160666 | 0.85 | JAK3 (0.46) | JAK3LCKBTKEGFR | |
| SCHEMBL30160759 | 0.83 | JAK3 (0.52) | JAK3LCKBTKEGFR | |
| SCHEMBL30160681 | 0.83 | JAK3 (0.52) | JAK3LCKBTKEGFR | |
| SCHEMBL31039905 | 0.83 | JAK3 (0.42) | JAK3LCKBTKEGFR | |
| SCHEMBL21946880 | 0.83 | JAK3 (0.70) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115003304-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 纽力克斯治疗公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-113412259-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 紐力克斯治疗公司 | 2021-09-17 | — | — | CN | disclosed |