Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 18/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 18/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.48 |
| ▸ | CDK2 | P24941 | 16/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 15/20 | 0.48 |
| ▸ | CDK9 | P50750 | 15/20 | 0.48 |
| ▸ | CDK7 | P50613 | 10/20 | 0.48 |
| ▸ | CCNH | P51946 | 10/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29583835 | 1.00 | CCNK (0.48) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL30359889 | 0.93 | CCNK (0.48) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL22076291 | 0.92 | CCNK (0.60) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29584307 | 0.92 | CCNK (0.60) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL30359967 | 0.89 | CCNK (0.47) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL22076297 | 0.89 | CCNK (0.54) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL30359979 | 0.85 | CDK2 (0.46) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL30359928 | 0.82 | CDK2 (0.45) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509256 | 0.82 | CCNE1 (0.43) | CCNKCDK12CCNE1CDK2CCNT1 | |
| SCHEMBL29509266 | 0.82 | CCNE1 (0.43) | CCNKCDK12CCNE1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113677346-A | Inhibitors of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2021-11-19 | — | — | CN | disclosed |
| CN-113226306-A | Methods of treating cancer in a patient identified by a biomarker using a non-covalent inhibitor of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2021-08-06 | — | — | CN | disclosed |