Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 4/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28649165 | 1.00 | MEN1 (0.41) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL28669783 | 0.96 | MEN1 (0.40) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL28669781 | 0.96 | MEN1 (0.40) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL28667038 | 0.92 | MEN1 (0.39) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL28667040 | 0.92 | MEN1 (0.39) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL20958044 | 0.84 | RGS12 (0.41) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL20958045 | 0.84 | RGS12 (0.41) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL28667047 | 0.79 | RGS12 (0.44) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL28667045 | 0.79 | RGS12 (0.44) | MEN1TP53GAAKMT2ACYP2D6 | |
| SCHEMBL349637 | 0.77 | RGS12 (0.42) | MEN1TP53GAAKMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113912617-A | Substituted tricycles and methods of use | 艾伯维公司 | 2022-01-11 | — | — | CN | disclosed |
| CN-108349930-B | Substituted tricycles and methods of use | 艾伯维公司 | 2021-10-29 | — | — | CN | disclosed |