Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | MGMT | P16455 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623370 | 1.00 | CUL4A (0.49) | CUL4ACYP1A2CYP2C9RPS6KB1KDM4E | |
| SCHEMBL30623376 | 0.86 | CUL4A (0.59) | CUL4ACYP1A2CYP2C9RPS6KB1ALDH1A1 | |
| SCHEMBL28644797 | 0.86 | CUL4A (0.59) | CUL4ACYP1A2CYP2C9RPS6KB1ALDH1A1 | |
| SCHEMBL30623383 | 0.85 | CUL4A (0.57) | CUL4ACYP1A2CYP2C9RPS6KB1ALDH1A1 | |
| SCHEMBL28650731 | 0.85 | CUL4A (0.57) | CUL4ACYP1A2CYP2C9RPS6KB1ALDH1A1 | |
| SCHEMBL12604551 | 0.81 | CUL4A (0.48) | CUL4ACYP1A2CYP2C9RPS6KB1CYP2C19 | |
| SCHEMBL3435512 | 0.80 | CUL4A (0.53) | CUL4ARPS6KB1ALDH1A1POLBHPGD | |
| SCHEMBL6948779 | 0.79 | HTT (0.52) | CUL4ACYP1A2CYP2C9RPS6KB1KDM4E | |
| SCHEMBL28648550 | 0.78 | CUL4A (0.51) | CUL4AMAPK1NPSR1HTT | |
| SCHEMBL30623361 | 0.78 | CUL4A (0.51) | CUL4AMAPK1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620976-B | Thiazolopyrimidine compound, preparation method, application and pharmaceutical composition thereof | 中国医学科学院药物研究所 | 2023-09-26 | — | — | CN | disclosed |
| CN-113620976-A | Thiazolopyrimidine compound and preparation method, application and pharmaceutical composition thereof | 中国医学科学院药物研究所 | 2021-11-09 | — | — | CN | disclosed |