Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 18/20 | 0.55 |
| ▸ | SMARCA2 | P51531 | 15/20 | 0.55 |
| ▸ | SMARCA4 | P51532 | 15/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL18038686 | 0.89 | PBRM1 (0.54) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL28650244 | 0.88 | PBRM1 (0.46) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| Trifluoroacetic Acid SCHEMBL30606983 | 0.85 | PBRM1 (0.58) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| Trifluoroacetic Acid SCHEMBL28663569 | 0.85 | PBRM1 (0.58) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18038834 | 0.85 | PBRM1 (0.61) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL26364083 | 0.84 | PBRM1 (0.62) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL26364088 | 0.84 | PBRM1 (0.62) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| Hydrochloric Acid SCHEMBL18038683 | 0.84 | PBRM1 (0.60) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL26364085 | 0.83 | PBRM1 (0.63) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL22959694 | 0.82 | PBRM1 (0.57) | PBRM1SMARCA2SMARCA4NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531668-B | Therapeutic pyridazine compounds and uses thereof | 基因泰克公司 | 2021-10-29 | — | — | CN | disclosed |