Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 19/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.84 |
| ▸ | ACHE | P22303 | 1/20 | 0.84 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mk-7145 SCHEMBL2894681 | 0.92 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Mk-7145 SCHEMBL297586 | 0.92 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Mk-7145 SCHEMBL297123 | 0.92 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Mk-7145 SCHEMBL29778244 | 0.92 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Mk-7145 SCHEMBL2894677 | 0.92 | KCNJ1 (1.00) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Mk-7145 SCHEMBL2898237 | 0.91 | KCNJ1 (0.97) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Mk-7145 SCHEMBL2897265 | 0.91 | KCNJ1 (0.97) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| Mk-7145 SCHEMBL2899446 | 0.90 | KCNJ1 (0.95) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL2895202 | 0.89 | KCNJ1 (0.88) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL16169896 | 0.89 | KCNJ1 (0.93) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632464-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129379-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |