Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 12/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19030210 | 0.91 | MAPT (0.48) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19030559 | 0.88 | IRAK4 (0.46) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL20531379 | 0.84 | MAPT (0.42) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19030853 | 0.83 | IRAK4 (0.46) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19030539 | 0.83 | IRAK4 (0.48) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19030247 | 0.82 | MAPT (0.38) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19030207 | 0.82 | IRAK4 (0.51) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19030796 | 0.81 | MAPT (0.45) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL23110722 | 0.81 | MAPT (0.42) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL19030431 | 0.80 | IRAK4 (0.50) | IRAK4MAPTALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |