Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 20/20 | 0.85 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30516475 | 1.00 | MAP3K14 (0.85) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL30516468 | 0.93 | MAP3K14 (0.84) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL28925231 | 0.93 | MAP3K14 (0.84) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL28638975 | 0.92 | MAP3K14 (1.00) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL30516447 | 0.92 | MAP3K14 (1.00) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL30516520 | 0.80 | MAP3K14 (0.85) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL30516451 | 0.79 | MAP3K14 (1.00) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL28645832 | 0.79 | MAP3K14 (1.00) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL28644241 | 0.77 | MAP3K14 (1.00) | MAP3K14JAK1JAK3TNK2NTRK3 | |
| SCHEMBL1614503 | 0.76 | MAP3K14 (0.73) | MAP3K14MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112794855-B | Preparation method and application of N-aryl pyrimidine-4-amine derivative | 中国药科大学 | 2023-07-28 | — | — | CN | claimed |
| CN-112794855-A | N-aryl pyrimidine-4-amine derivative and application thereof | 中国药科大学 | 2021-05-14 | — | — | CN | claimed |
| CN-112794855-B | Preparation method and application of N-aryl pyrimidine-4-amine derivative | 中国药科大学 | 2023-07-28 | — | — | CN | disclosed |
| CN-112794855-A | N-aryl pyrimidine-4-amine derivative and application thereof | 中国药科大学 | 2021-05-14 | — | — | CN | disclosed |