Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 15/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286354 | 0.84 | KCNJ1 (0.46) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL22718938 | 0.78 | KCNJ1 (0.62) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL287086 | 0.74 | PDCD1 (0.39) | PDCD1CD274 | |
| SCHEMBL23513349 | 0.72 | KCNJ1 (0.44) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL23496685 | 0.69 | KCNJ1 (0.44) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL23496739 | 0.69 | KCNJ1 (0.47) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19264534 | 0.67 | KCNJ1 (0.68) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL2897757 | 0.67 | KCNJ1 (0.40) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL15036782 | 0.66 | KCNJ1 (0.64) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL19433455 | 0.66 | KCNJ1 (0.66) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |