Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.71 |
| ▸ | HTR2A | P28223 | 4/20 | 0.71 |
| ▸ | HTR2B | P41595 | 4/20 | 0.71 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29287872 | 0.90 | HTR2C (0.75) | HTR2CHTR2AHTR2BADRB2SLC6A4 | |
| SCHEMBL30298946 | 0.83 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB2SLC6A4 | |
| SCHEMBL20656986 | 0.83 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB2SLC6A4 | |
| SCHEMBL25545639 | 0.83 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB2SLC6A4 | |
| SCHEMBL20656985 | 0.83 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB2SLC6A4 | |
| SCHEMBL19889366 | 0.81 | HTR2C (0.57) | HTR2CHTR2AHTR2BADRB2SLC6A4 | |
| SCHEMBL3239993 | 0.81 | HTR2C (0.57) | HTR2CHTR2AHTR2BADRB2SLC6A4 | |
| SCHEMBL8409219 | 0.79 | HTR2A (0.50) | HTR2CHTR2AHTR2BSLC6A4KDM4E | |
| SCHEMBL7819547 | 0.79 | HTR2A (0.50) | HTR2CHTR2AHTR2BSLC6A4KDM4E | |
| SCHEMBL8407526 | 0.79 | HTR2C (0.44) | HTR2CHTR2AHTR2BADRB2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108864080-B | Tetracyclic compounds as selective estrogen receptor down-regulating agents and application thereof | 南京圣和药业股份有限公司 | 2021-10-15 | — | — | CN | disclosed |