SCHEMBL28658281

SCHEMBL28658281

CC(I)CCc1ccc(OC(F)(F)F)cc1

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 5/20 0.44
EPHX1 P07099 1/20 0.43
ALDH1A1 P00352 1/20 0.43
TSHR P16473 1/20 0.43
SLC6A3 Q01959 4/20 0.43
DAO P14920 1/20 0.42
ACACB O00763 1/20 0.41
PDE2A O00408 1/20 0.41
GPR84 Q9NQS5 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
SCN9A Q15858 1/20 0.39
BCHE P06276 1/20 0.38
ACHE P22303 1/20 0.38
GRIN2B Q13224 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
LTA4H P09960 1/20 0.38
EPHX2 P34913 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19043747 0.86 SLC6A4 (0.46) SLC6A4EPHX1ALDH1A1TSHRSLC6A3
SCHEMBL23718447 0.79 TSHR (0.43) SLC6A4EPHX1ALDH1A1TSHRSLC6A3
SCHEMBL28676699 0.77 POLB (0.49) ALDH1A1ACACBKMT2AHTTSMN1; SMN2
SCHEMBL23269923 0.77 TMEM97 (0.53) ALDH1A1DAOMEN1KMT2A
SCHEMBL29483421 0.76 BCHE (0.46) SLC6A4EPHX1SLC6A3DAOACACB
SCHEMBL700041 0.76 DAO (0.51) SLC6A4EPHX1ALDH1A1TSHRSLC6A3
SCHEMBL9062148 0.76 TSHR (0.53) SLC6A4ALDH1A1TSHRSLC6A3DAO
SCHEMBL1687455 0.76 TSHR (0.53) SLC6A4ALDH1A1TSHRSLC6A3DAO
SCHEMBL28642895 0.75 NQO1 (0.52) TSHRACACBMEN1KMT2ABCHE
SCHEMBL28662592 0.75 ACACB (0.44) ALDH1A1ACACBMEN1KMT2ABCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113511991-B Synthesis method of halogenated alkane thioetherification and thiocarbonylation 安徽农业大学 2022-05-20 CN disclosed
CN-113511991-A Synthesis method for thioatherification and thiocarbonylation of halogenated alkane 安徽农业大学 2021-10-19 CN disclosed