Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 19/20 | 0.49 |
| ▸ | ALB | P02768 | 2/20 | 0.49 |
| ▸ | BCL2 | P10415 | 5/20 | 0.42 |
| ▸ | PMAIP1 | Q13794 | 2/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | EEF2K | O00418 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | NEK4 | P51957 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28643047 | 0.98 | MCL1 (0.50) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL19615250 | 0.94 | MCL1 (0.50) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL19634963 | 0.93 | MCL1 (0.43) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL19615375 | 0.92 | MCL1 (0.51) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL19635831 | 0.91 | MCL1 (0.44) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL19615246 | 0.87 | MCL1 (0.44) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL28652809 | 0.87 | MCL1 (0.58) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL28656194 | 0.86 | MCL1 (0.56) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL28647049 | 0.86 | MCL1 (0.55) | MCL1ALBBCL2PMAIP1BCL2L1 | |
| SCHEMBL28642379 | 0.86 | MCL1 (0.54) | MCL1ALBBCL2PMAIP1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715632-B | Macrocyclic indole derivatives | 拜尔公开股份有限公司 | 2021-10-26 | — | — | CN | disclosed |