Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | MGMT | P16455 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25258863 | 0.87 | CHRM2 (0.54) | SLC6A4MGMTDRD4SIGMAR1 | |
| SCHEMBL12120447 | 0.87 | CHRM2 (0.54) | SLC6A4MGMTDRD4SIGMAR1 | |
| SCHEMBL25258864 | 0.87 | CHRM2 (0.54) | SLC6A4MGMTDRD4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL31400380 | 0.86 | CHRM2 (0.52) | SLC6A4MGMTDRD4SIGMAR1 | |
| SCHEMBL1001296 | 0.85 | CHRM2 (0.58) | SLC6A4MGMTDRD4SIGMAR1ALDH1A1 | |
| SCHEMBL8310750 | 0.83 | SLC6A4 (0.50) | SLC6A4MGMTDRD4SIGMAR1ALDH1A1 | |
| SCHEMBL15477305 | 0.81 | DRD4 (0.51) | SLC6A4MGMTDRD4SIGMAR1SYK | |
| SCHEMBL3920378 | 0.78 | DRD4 (0.49) | SLC6A4MGMTDRD4SIGMAR1SYK | |
| Hydrochloric Acid SCHEMBL7924437 | 0.76 | SLC6A4 (0.42) | SLC6A4MGMTDRD4SIGMAR1SYK | |
| SCHEMBL536843 | 0.74 | DRD4 (0.44) | SLC6A4MGMTDRD4SIGMAR1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-B | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2021-12-14 | — | — | CN | disclosed |