Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.66 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.66 |
| ▸ | MTOR | P42345 | 11/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.66 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.66 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | PAK4 | O96013 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | FGR | P09769 | 1/20 | 0.66 |
| ▸ | FER | P16591 | 1/20 | 0.66 |
| ▸ | PRKCA | P17252 | 1/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | TEC | P42680 | 1/20 | 0.66 |
| ▸ | SYK | P43405 | 1/20 | 0.66 |
| ▸ | PRKDC | P78527 | 1/20 | 0.66 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.66 |
| ▸ | BTK | Q06187 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Apitolisib SCHEMBL31270275 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| Apitolisib SCHEMBL466298 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| Apitolisib SCHEMBL29447291 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| Apitolisib SCHEMBL466297 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| Apitolisib SCHEMBL1180678 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL29127748 | 0.78 | PIK3CA (0.77) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL29127750 | 0.78 | PIK3CA (0.77) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL1181037 | 0.74 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL1182231 | 0.74 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG | |
| SCHEMBL1181040 | 0.74 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901662-A | Bicyclic heteroaryl compounds and uses thereof | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-113767100-A | Bicyclic heteroaryl compounds and uses thereof | 锐新医药公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-113727758-A | Bicyclic heterocyclic compounds and use thereof | 锐新医药公司 | 2021-11-30 | — | — | CN | disclosed |