Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 6/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2866703 | 1.00 | NOTUM (0.45) | NOTUMKDM1AHTR2CP2RY14S1PR4 | |
| SCHEMBL2866707 | 1.00 | NOTUM (0.45) | NOTUMKDM1AHTR2CP2RY14S1PR4 | |
| Hydrochloric Acid SCHEMBL2860536 | 0.99 | HTR2C (0.44) | NOTUMKDM1AHTR2CP2RY14S1PR4 | |
| Hydrochloric Acid SCHEMBL2860539 | 0.99 | HTR2C (0.44) | NOTUMKDM1AHTR2CP2RY14S1PR4 | |
| Hydrochloric Acid SCHEMBL2860531 | 0.99 | HTR2C (0.44) | NOTUMKDM1AHTR2CP2RY14S1PR4 | |
| SCHEMBL4505964 | 0.84 | TDP1 (0.44) | KDM1AHTR2CP2RY14 | |
| SCHEMBL581068 | 0.84 | TDP1 (0.44) | KDM1AHTR2CP2RY14 | |
| Hydrochloric Acid SCHEMBL4504270 | 0.83 | TDP1 (0.44) | KDM1AHTR2CP2RY14 | |
| SCHEMBL29891340 | 0.82 | AKR1C3 (0.54) | NOTUMS1PR4S1PR1S1PR3S1PR5 | |
| SCHEMBL31424170 | 0.82 | AKR1C3 (0.54) | NOTUMS1PR4S1PR1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |
| EP-1805141-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |