Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 12/20 | 0.71 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 4/20 | 0.61 |
| ▸ | MAP4K3 | Q8IVH8 | 4/20 | 0.61 |
| ▸ | IL2 | P60568 | 1/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.52 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30290652 | 0.91 | MAP4K1 (0.70) | MAP4K1LCKMAP4K3IL2 | |
| SCHEMBL28692421 | 0.91 | MAP4K1 (0.70) | MAP4K1LCKMAP4K3IL2 | |
| SCHEMBL30290525 | 0.89 | MAP4K1 (0.72) | MAP4K1LCKMAP4K3IL2 | |
| SCHEMBL28931337 | 0.89 | MAP4K1 (0.72) | MAP4K1LCKMAP4K3IL2 | |
| SCHEMBL30290655 | 0.87 | MAP4K1 (0.71) | MAP4K1FYNLCKMAP4K3IL2 | |
| SCHEMBL28674204 | 0.87 | MAP4K1 (0.71) | MAP4K1FYNLCKMAP4K3IL2 | |
| SCHEMBL30290501 | 0.86 | MAP4K1 (0.69) | MAP4K1LCKMAP4K3IL2 | |
| SCHEMBL28683749 | 0.86 | MAP4K1 (0.69) | MAP4K1LCKMAP4K3IL2 | |
| SCHEMBL28684666 | 0.86 | MAP4K1 (0.72) | MAP4K1LCKMAP4K3IL2 | |
| SCHEMBL30290593 | 0.85 | MAP4K1 (0.57) | MAP4K1LCKMAP4K3IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861188-B | Pyrazolo [3,4-b ] pyridine derivative, preparation method thereof and application thereof as HPK1 inhibitor | 杭州医学院 | 2023-02-28 | — | — | CN | disclosed |
| CN-113861188-A | Pyrazolo [3,4-b ] pyridine derivative, preparation method thereof and application thereof as HPK1 inhibitor | 杭州医学院 | 2021-12-31 | — | — | CN | disclosed |