Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 15/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.55 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | IL2 | P60568 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30290646 | 1.00 | MAP4K1 (0.58) | MAP4K1LCKMAP4K3HTR6ALK | |
| SCHEMBL30290664 | 0.90 | MAP4K1 (0.59) | MAP4K1LCKMAP4K3HTR6ALK | |
| SCHEMBL28667560 | 0.90 | MAP4K1 (0.59) | MAP4K1LCKMAP4K3HTR6ALK | |
| SCHEMBL30290514 | 0.90 | MAP4K1 (0.59) | MAP4K1LCKMAP4K3HTR6ALK | |
| SCHEMBL28674247 | 0.90 | MAP4K1 (0.59) | MAP4K1LCKMAP4K3HTR6ALK | |
| SCHEMBL30290614 | 0.89 | MAP4K1 (0.57) | MAP4K1LCKMAP4K3HTR6ALK | |
| SCHEMBL28687893 | 0.89 | MAP4K1 (0.57) | MAP4K1LCKMAP4K3HTR6ALK | |
| SCHEMBL28682125 | 0.87 | MAP4K1 (0.73) | MAP4K1LCKMAP4K3ALKKIT | |
| SCHEMBL28684666 | 0.86 | MAP4K1 (0.72) | MAP4K1LCKMAP4K3IL2 | |
| SCHEMBL30290623 | 0.86 | MAP4K1 (0.72) | MAP4K1LCKMAP4K3IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113861188-A | Pyrazolo [3,4-b ] pyridine derivative, preparation method thereof and application thereof as HPK1 inhibitor | 杭州医学院 | 2021-12-31 | — | — | CN | disclosed |