Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20070064 | 1.00 | RET (0.51) | RETHSD11B1HRH3ALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL29971002 | 0.94 | RET (0.47) | RETHSD11B1HRH3ALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL20137739 | 0.94 | RET (0.47) | RETHSD11B1HRH3ALDH1A1LMNA | |
| SCHEMBL22856984 | 0.90 | RET (0.54) | RETHSD11B1HRH3ALDH1A1LMNA | |
| SCHEMBL20069617 | 0.89 | RET (0.53) | RETHSD11B1HRH3ALDH1A1LMNA | |
| SCHEMBL20137706 | 0.87 | RET (0.52) | RETHSD11B1HRH3ALDH1A1LMNA | |
| SCHEMBL20137709 | 0.87 | RET (0.52) | RETHSD11B1HRH3ALDH1A1LMNA | |
| SCHEMBL21651952 | 0.86 | RET (0.51) | RETHSD11B1HRH3ALDH1A1LMNA | |
| SCHEMBL20206010 | 0.86 | RET (0.51) | RETHSD11B1HRH3ALDH1A1LMNA | |
| SCHEMBL25502425 | 0.86 | RET (0.51) | RETHSD11B1HRH3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177786-B | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2021-12-14 | — | — | CN | disclosed |