Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | KRAS | P01116 | 2/20 | 0.49 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29898247 | 1.00 | EGFR (0.51) | EGFRABCG2KRASSOS1PDE1B | |
| SCHEMBL28691836 | 0.83 | GALR3 (0.45) | EGFRABCG2KDRHPGDHTT | |
| SCHEMBL29898304 | 0.82 | PDE1B (0.47) | EGFRABCG2KRASSOS1PDE1B | |
| SCHEMBL28682743 | 0.82 | PDE1B (0.47) | EGFRABCG2KRASSOS1PDE1B | |
| SCHEMBL28693417 | 0.82 | EGFR (0.62) | EGFRABCG2KDRBRD4ERBB2 | |
| SCHEMBL28765458 | 0.76 | KMT2A (0.38) | KDM4ELMNAHPGD | |
| SCHEMBL30038700 | 0.76 | KMT2A (0.38) | KDM4ELMNAHPGD | |
| SCHEMBL28765459 | 0.76 | KMT2A (0.38) | KDM4ELMNAHPGD | |
| SCHEMBL30039552 | 0.74 | KMT2A (0.36) | KDM4ELMNAHPGD | |
| SCHEMBL28765601 | 0.74 | KMT2A (0.36) | KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113754636-B | Quinazoline-containing aza-ether compounds | 湖南化工研究院有限公司 | 2022-10-04 | — | — | CN | claimed |
| CN-113754636-A | Quinazoline-containing aza-ether compounds | 湖南化工研究院有限公司 | 2021-12-07 | — | — | CN | claimed |