Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 4/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Proline SCHEMBL16241649 | 1.00 | MEN1 (0.47) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL27146870 | 0.94 | MEN1 (0.42) | MEN1BLMKMT2ANOS2NOS3 | |
| D-Proline SCHEMBL27138421 | 0.94 | MEN1 (0.42) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL28049461 | 0.93 | MEN1 (0.48) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL13248912 | 0.93 | — | — | |
| Proline SCHEMBL2939 | 0.93 | — | — | |
| Proline SCHEMBL6894672 | 0.93 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL10141185 | 0.93 | — | — | |
| D-Proline SCHEMBL21462052 | 0.93 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 | |
| Proline SCHEMBL462225 | 0.93 | BLM (0.52) | MEN1BLMKMT2ANOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113993587-A | Thiazole derivatives as protein secretion inhibitors | 科智生命科学公司 | 2022-01-28 | — | — | CN | disclosed |