Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.54 |
| ▸ | JAK2 | O60674 | 5/20 | 0.53 |
| ▸ | CDK4 | P11802 | 7/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.51 |
| ▸ | CCND1 | P24385 | 3/20 | 0.51 |
| ▸ | CCND2 | P30279 | 3/20 | 0.51 |
| ▸ | CCND3 | P30281 | 3/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29370779 | 1.00 | CDK2 (0.54) | CDK2CCNE1JAK2CDK4KDR | |
| SCHEMBL28687081 | 0.99 | CDK4 (0.54) | CDK2CCNE1JAK2CDK4KDR | |
| SCHEMBL29371706 | 0.99 | CDK4 (0.54) | CDK2CCNE1JAK2CDK4KDR | |
| SCHEMBL28714706 | 0.84 | HDAC6 (0.63) | JAK2CDK4AURKACCND3HDAC6 | |
| SCHEMBL28714813 | 0.83 | HDAC6 (0.62) | JAK2CDK4AURKACCND3HDAC6 | |
| SCHEMBL29370753 | 0.83 | CDK4 (0.69) | CDK2CCNE1JAK2CDK4KDR | |
| SCHEMBL28687755 | 0.83 | CDK4 (0.69) | CDK2CCNE1JAK2CDK4KDR | |
| SCHEMBL29368374 | 0.82 | CDK4 (0.68) | CDK2CCNE1JAK2CDK4KDR | |
| SCHEMBL28689771 | 0.82 | CDK4 (0.68) | CDK2CCNE1JAK2CDK4KDR | |
| SCHEMBL28676599 | 0.81 | CDK2 (0.57) | CDK2CCNE1JAK2CDK4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999210-B | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2023-05-23 | — | — | CN | claimed |
| CN-113999210-A | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-02-01 | — | — | CN | claimed |
| CN-113999210-B | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2023-05-23 | — | — | CN | disclosed |
| CN-113999210-A | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2022-02-01 | — | — | CN | disclosed |