Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | CTSV | O60911 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSH | P09668 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CASP14 | P31944 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14029994 | 0.94 | KMT2A (0.40) | TRPV4MEN1KMT2AL3MBTL1CTSV | |
| SCHEMBL3624322 | 0.93 | PIM1 (0.43) | PIM1PIM2ROCK2TDP1 | |
| SCHEMBL3624321 | 0.93 | PIM1 (0.43) | PIM1PIM2ROCK2TDP1 | |
| SCHEMBL29427903 | 0.90 | MAPK1 (0.36) | TRPV4PIM1PIM2MEN1KMT2A | |
| SCHEMBL3631931 | 0.90 | MAPK1 (0.36) | TRPV4PIM1PIM2MEN1KMT2A | |
| SCHEMBL12820367 | 0.87 | SCN5A (0.35) | PIM1PIM2MEN1KMT2AL3MBTL1 | |
| SCHEMBL3630162 | 0.84 | BCL6 (0.36) | GRM2IRAK4CTSK | |
| SCHEMBL3630158 | 0.84 | BCL6 (0.36) | GRM2IRAK4CTSK | |
| SCHEMBL5005581 | 0.79 | PTGS1 (0.36) | PIM1PDE4BIRAK4 | |
| SCHEMBL5005536 | 0.79 | PTGS1 (0.34) | PIM1MEN1KMT2ANPC1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113767106-B | Oxazaquinazolin-7 (8H) -ones, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2024-02-20 | — | — | CN | disclosed |
| US-20220251109-A1 | OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | GENFLEET THERAPEUTICS (SHANGHAI) INC. (CN) | 2022-08-11 | — | — | US | disclosed |
| EP-3964516-A1 | OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THERFOR AND PHARMACEUTICAL APPLICATION THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2022-03-09 | — | — | EP | disclosed |
| CN-113767106-A | Oxaazaquinazolin-7 (8H) -ones, their preparation and pharmaceutical use | 劲方医药科技(上海)有限公司 | 2021-12-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220251109-A1 | OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | KRAS, NRAS, WEE1 | TRPV4 4382/4885PIM1 1277/4885PIM2 1757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.