Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.84 |
| ▸ | INSR | P06213 | 16/20 | 0.84 |
| ▸ | IGF1R | P08069 | 16/20 | 0.84 |
| ▸ | AURKA | O14965 | 2/20 | 0.79 |
| ▸ | ROS1 | P08922 | 2/20 | 0.79 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.79 |
| ▸ | EGFR | P00533 | 2/20 | 0.78 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.76 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.76 |
| ▸ | JAK2 | O60674 | 1/20 | 0.76 |
| ▸ | STK10 | O94804 | 1/20 | 0.76 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.76 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.76 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.76 |
| ▸ | ABL1 | P00519 | 1/20 | 0.76 |
| ▸ | CD74 | P04233 | 1/20 | 0.76 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.76 |
| ▸ | LCK | P06239 | 1/20 | 0.76 |
| ▸ | FYN | P06241 | 1/20 | 0.76 |
| ▸ | FES | P07332 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11916595 | 0.92 | ALK (0.86) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916443 | 0.92 | ALK (1.00) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916456 | 0.91 | ALK (0.85) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL30180253 | 0.91 | ALK (0.85) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL21135587 | 0.91 | ALK (0.86) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL24818137 | 0.91 | ALK (0.83) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916574 | 0.91 | ALK (0.86) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916432 | 0.91 | ALK (1.00) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL21133486 | 0.90 | ALK (0.85) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916602 | 0.90 | ALK (0.85) | ALKINSRIGF1RAURKAROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112079866-B | ALK protein regulator and anti-tumor application thereof | 上海科技大学 | 2024-05-31 | — | — | CN | disclosed |
| CN-109912655-B | ALK protein degradation agent and anti-tumor application thereof | 上海科技大学 | 2021-12-10 | — | — | CN | disclosed |
| CN-112079866-A | ALK protein regulator and anti-tumor application thereof | 上海科技大学 | 2020-12-15 | — | — | CN | disclosed |