Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24113030 | 0.87 | HPGD (0.49) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL28994850 | 0.87 | HPGD (0.49) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL29890877 | 0.87 | HPGD (0.49) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL24766074 | 0.87 | HPGD (0.49) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL30540076 | 0.87 | HPGD (0.49) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL24766583 | 0.87 | HPGD (0.49) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL28850128 | 0.87 | HPGD (0.49) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL28682790 | 0.86 | HPGD (0.46) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL26666954 | 0.86 | HPGD (0.46) | HPGDRECQLEPHX1MAPTMEN1 | |
| SCHEMBL26666953 | 0.84 | HPGD (0.43) | HPGDRECQLEPHX1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022060996-A1 | INHIBITORS OF RAF KINASES | KINNATE BIOPHARMA INC. (US) | 2022-03-24 | — | — | WO | disclosed |
| CN-113874381-A | Inhibitors of RAF kinase | 金耐特生物制药公司 | 2021-12-31 | — | — | CN | disclosed |