SCHEMBL28683174

SCHEMBL28683174

O=C1OC=CCN1Cc1cncc(-c2ccc(Cl)c(OC(F)F)c2)n1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIN1 Q05586 20/20 0.69
GRIN2B Q13224 20/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28677510 0.90 GRIN1 (0.71) GRIN1GRIN2B
SCHEMBL28691028 0.83 GRIN1 (0.90) GRIN1GRIN2B
SCHEMBL28687550 0.83 GRIN1 (0.72) GRIN1GRIN2B
SCHEMBL22772473 0.82 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL22772471 0.81 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL22772509 0.81 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL22772459 0.81 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL22772481 0.81 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL22772457 0.81 GRIN1 (1.00) GRIN1GRIN2B
SCHEMBL29527134 0.81 GRIN1 (1.00) GRIN1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113950357-A Pyrazine carbamates and their use as GluN2B receptor modulators 詹森药业有限公司 2022-01-18 CN claimed
CN-113950357-A Pyrazine carbamates and their use as GluN2B receptor modulators 詹森药业有限公司 2022-01-18 CN disclosed