Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.59 |
| ▸ | NTRK3 | Q16288 | 6/20 | 0.59 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.59 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28686131 | 0.83 | NTRK1 (0.46) | NTRK1NTRK3NTRK2GRM4 | |
| SCHEMBL28708451 | 0.81 | NTRK1 (0.49) | NTRK1NTRK3NTRK2GRM5LRRK2 | |
| SCHEMBL28697267 | 0.80 | NTRK1 (0.64) | NTRK1NTRK3NTRK2 | |
| SCHEMBL28700912 | 0.80 | NTRK1 (0.59) | NTRK1NTRK3NTRK2GRM5GRM4 | |
| SCHEMBL28684850 | 0.78 | NTRK1 (0.38) | NTRK1NTRK3NTRK2GRM5 | |
| SCHEMBL28686122 | 0.78 | NTRK1 (0.60) | NTRK1NTRK3NTRK2LRRK2GRM4 | |
| SCHEMBL28698672 | 0.76 | NTRK1 (0.53) | NTRK1NTRK3NTRK2GRM5 | |
| SCHEMBL12269783 | 0.75 | LRRK2 (0.49) | GRM5TTKLRRK2 | |
| SCHEMBL28690954 | 0.75 | NTRK1 (0.54) | NTRK1NTRK3NTRK2 | |
| SCHEMBL28690940 | 0.74 | NTRK3 (1.00) | NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114072387-B | Indazole compound, pharmaceutical composition and application thereof | 暨南大学 | 2024-03-08 | — | — | CN | disclosed |
| CN-114072387-A | Indazole compound and medicinal composition and application thereof | 暨南大学 | 2022-02-18 | — | — | CN | disclosed |