Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 10/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.47 |
| ▸ | CDK9 | P50750 | 9/20 | 0.47 |
| ▸ | CDK1 | P06493 | 6/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.47 |
| ▸ | CDK7 | P50613 | 5/20 | 0.47 |
| ▸ | CCNH | P51946 | 5/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28689804 | 0.91 | EGFR (0.56) | EGFRCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL28931694 | 0.87 | EGFR (0.58) | EGFRCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL18376747 | 0.84 | EGFR (0.59) | EGFRCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL18376832 | 0.84 | JAK2 (0.58) | EGFRCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL28690545 | 0.84 | EGFR (0.54) | EGFRCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL28120721 | 0.83 | TTK (0.49) | EGFRCDK2CCNT1CDK9JAK3 | |
| SCHEMBL29368834 | 0.83 | EGFR (0.62) | EGFRCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL18376840 | 0.83 | EGFR (0.62) | EGFRCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL18376839 | 0.82 | EGFR (0.53) | EGFRCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL18376844 | 0.82 | EGFR (0.65) | EGFRCDK2CCNT1CCNA2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |