Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24943526 | 0.84 | HDAC1 (0.41) | HDAC1SMN1; SMN2KMT2ALMNAXDH | |
| SCHEMBL15897416 | 0.82 | PTPN2 (0.43) | HDAC1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL29750908 | 0.79 | PTPN11 (0.47) | HDAC1HTTLCKCA12CA1 | |
| SCHEMBL1623079 | 0.79 | PTPN11 (0.47) | HDAC1HTTLCKCA12CA1 | |
| SCHEMBL31162850 | 0.77 | HDAC1 (0.44) | HDAC1MEN1KMT2AMAPTHPGD | |
| SCHEMBL15774244 | 0.77 | HDAC1 (0.44) | HDAC1MEN1KMT2AMAPTHPGD | |
| SCHEMBL20928226 | 0.77 | SNCA (0.52) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL14249475 | 0.76 | HDAC1 (0.49) | HDAC1MEN1KMT2AMAPTHPGD | |
| SCHEMBL1886145 | 0.76 | HDAC1 (0.80) | HDAC1PIK3CAPIK3CBPIK3CGPI4KB | |
| SCHEMBL1886911 | 0.75 | HDAC1 (0.78) | HDAC1PIK3CAPIK3CBPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114075189-A | Five-membered heterocyclic acene ring compound and preparation method and medical application thereof | 南京柯菲平盛辉制药有限公司 | 2022-02-22 | — | — | CN | disclosed |