⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16299498 | 0.85 | — | — | |
| SCHEMBL9005251 | 0.74 | — | — | |
| SCHEMBL127456 | 0.72 | TSHR (0.39) | — | |
| SCHEMBL29002914 | 0.72 | — | — | |
| SCHEMBL9751404 | 0.69 | — | — | |
| Water SCHEMBL30631870 | 0.69 | — | — | |
| Water SCHEMBL30631869 | 0.67 | — | — | |
| SCHEMBL22440711 | 0.67 | CYP2C19 (0.32) | — | |
| SCHEMBL22440705 | 0.65 | GAA (0.33) | — | |
| SCHEMBL23829590 | 0.62 | TSHR (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576686-B1 | CELL | DAI ICHI KOGYO SEIYAKU CO LTD (JP) | 2001-10-10 | — | — | EP | claimed |
| EP-2095833-B1 | Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices | CARDINAL HEALTH 515 GMBH (CH) | 2019-08-28 | — | — | EP | disclosed |
| US-9603980-B2 | Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices | CARDINAL HEALTH SWITZERLAND 515 GmbH (CH) | 2017-03-28 | — | — | US | disclosed |
| EP-3056229-A2 | THE LOCAL ADMINISTRATION OF A COMBINATION OF RAPAMYCIN AND 17 BETA-ESTRADIOL FOR THE TREATMENT OF VULNERABLE PLAQUE | Cordis Corporation (US) | 2016-08-17 | — | — | EP | disclosed |
| US-9402804-B2 | Injectable formulations of taxanes for cad treatment | CARDINAL HEALTH SWITZERLAND 515 GmbH (CH) | 2016-08-02 | — | — | US | disclosed |
| EP-1591108-B1 | Solution formulations of sirolimus and its analogs for CAD treatment | CORDIS CORP (US) | 2016-03-16 | — | — | EP | disclosed |
| US-8871240-B2 | Rapamycin coated expandable devices | CORDIS CORPORATION | 2014-10-28 | — | — | US | disclosed |
| US-8784860-B2 | Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease | CORDIS CORPORATION | 2014-07-22 | — | — | US | disclosed |
| US-8747881-B2 | Intraluminal medical devices in combination with therapeutic agents | CORDIS CORPORATION | 2014-06-10 | — | — | US | disclosed |
| US-20140004254-A1 | THERAPEUTIC AGENT ELUTION CONTROL PROCESS | CORDIS US CORP | 2014-01-02 | — | — | US | disclosed |
| EP-1591108-A2 | Solution formulations of sirolimus and its analogs for CAD treatment | Cordis Corporation (US) | 2005-11-02 | — | — | EP | disclosed |
| US-20050232964-A1 | Use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices | WYETH | 2005-10-20 | — | — | US | disclosed |
| US-20050232965-A1 | Local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque | WYETH | 2005-10-20 | — | — | US | disclosed |
| EP-1586337-A2 | The local administration of a combination of rapamycin and 17 beta-estradiol for the treatment of vulnerable plaque | Cordis Corporation (US) | 2005-10-19 | — | — | EP | disclosed |
| EP-1586338-A2 | The use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices | Cordis Corporation (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20050222191-A1 | Solution formulations of sirolimus and its analogs for CAD treatment | WYETH | 2005-10-06 | — | — | US | disclosed |
| US-20050004663-A1 | Heparin barrier coating for controlled drug release | WYETH | 2005-01-06 | — | — | US | disclosed |
| EP-0576686-B1 | CELL | DAI ICHI KOGYO SEIYAKU CO LTD (JP) | 2001-10-10 | — | — | EP | disclosed |
| CN-1045710-C | Pesticidal 1-arylimidazoles | RHONE POULENC AGROCHIMIE (FR) | 1999-10-20 | — | — | CN | disclosed |
| CN-1046898-A | 1-Aryimidazole insecticides | RHONE POULENC AGROCHIMIE (FR) | 1990-11-14 | — | — | CN | disclosed |