Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.55 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23450760 | 0.88 | EGFR (0.73) | EGFRERBB2KDRLCK | |
| SCHEMBL23406678 | 0.87 | EGFR (0.68) | EGFRERBB2KDR | |
| SCHEMBL23450759 | 0.87 | EGFR (0.68) | EGFRERBB2KDR | |
| SCHEMBL23450824 | 0.87 | EGFR (0.68) | EGFRERBB2KDR | |
| SCHEMBL23450804 | 0.87 | EGFR (0.70) | EGFRERBB2KDRERBB3DUS2 | |
| SCHEMBL23451043 | 0.86 | EGFR (0.77) | EGFRERBB2ERBB3DUS2LCK | |
| SCHEMBL21835262 | 0.86 | EGFR (0.69) | EGFRERBB2KDRLCK | |
| SCHEMBL23450872 | 0.86 | EGFR (0.69) | EGFRERBB2KDRLCK | |
| SCHEMBL23450784 | 0.85 | EGFR (0.66) | EGFRERBB2KDRERBB3LCK | |
| SCHEMBL28703633 | 0.85 | EGFR (0.54) | EGFRERBB2ERBB3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113382986-A | Tyrosine kinase inhibitor compositions, methods of making and methods of using the same | 黑钻治疗公司 | 2021-09-10 | — | — | CN | disclosed |