Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.67 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | AHR | P35869 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29414588 | 0.78 | MAP3K14 (0.60) | MAP3K14AKR1B1AHRALDH1A1GAA | |
| SCHEMBL19285552 | 0.78 | MAP3K14 (0.60) | MAP3K14AKR1B1AHRALDH1A1GAA | |
| SCHEMBL19284979 | 0.77 | MAP3K14 (0.57) | MAP3K14AKR1B1MAPTNPC1RAB9A | |
| SCHEMBL28970256 | 0.76 | MAP3K14 (0.57) | MAP3K14AKR1B1ALDH1A1GAAMAPT | |
| SCHEMBL28970233 | 0.76 | MAP3K14 (0.57) | MAP3K14AKR1B1ALDH1A1GAAMAPT | |
| SCHEMBL23976814 | 0.76 | MAP3K14 (0.57) | MAP3K14AKR1B1ALDH1A1GAAMAPT | |
| SCHEMBL23976493 | 0.74 | MAP3K14 (0.55) | MAP3K14AKR1B1ALDH1A1MAPTNPC1 | |
| SCHEMBL28807542 | 0.73 | MAP3K14 (0.39) | MAP3K14AKR1B1 | |
| SCHEMBL21930582 | 0.70 | MAP3K14 (0.56) | MAP3K14AKR1B1MAPTNPC1 | |
| SCHEMBL21930580 | 0.70 | MAP3K14 (0.56) | MAP3K14AKR1B1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114096546-A | Macrocyclic spirocyclic derivatives useful as MCL-1 inhibitors | 詹森药业有限公司 | 2022-02-25 | — | — | CN | disclosed |