Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 8/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3502708 | 0.86 | JAK2 (0.49) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL2862333 | 0.85 | JAK2 (0.73) | JAK2CSNK2A1 | |
| SCHEMBL3500457 | 0.77 | JAK2 (0.71) | JAK2 | |
| SCHEMBL2877188 | 0.69 | JAK2 (0.68) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL2879082 | 0.66 | JAK2 (0.46) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3500922 | 0.66 | JAK2 (0.88) | JAK2 | |
| SCHEMBL2876749 | 0.66 | JAK2 (0.60) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL2869677 | 0.66 | JAK2 (1.00) | JAK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL30601032 | 0.65 | — | — | |
| SCHEMBL30544790 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | claimed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | claimed |
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |