SCHEMBL28704875

SCHEMBL28704875

Cc1nc2cc(C(F)(F)F)cc(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1cc(Cl)nc2c(C(=O)O)csc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
EIF4EBP1 Q13541 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29650476 0.95 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866775 0.95 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL28717573 0.94 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29661893 0.94 EIF4EBP1 (0.88) EIF4EBP1
SCHEMBL22866456 0.94 EIF4EBP1 (0.88) EIF4EBP1
SCHEMBL22866457 0.92 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29661935 0.92 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650427 0.92 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29561363 0.88 EIF4EBP1 (0.88) EIF4EBP1
SCHEMBL22866776 0.87 EIF4EBP1 (1.00) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114269756-B 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E 效应疗法股份有限公司 2024-05-14 CN disclosed
CN-114269756-A 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E 效应疗法股份有限公司 2022-04-01 CN disclosed