Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 15/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731306 | 0.82 | KCNJ1 (1.00) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL286800 | 0.81 | KCNJ1 (0.84) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL286799 | 0.81 | KCNJ1 (0.74) | KCNJ1KCNH2HRH3SIGMAR1HTR2A | |
| SCHEMBL286525 | 0.80 | KCNJ1 (0.68) | KCNJ1KCNH2HRH3SIGMAR1HTR2A | |
| SCHEMBL3839516 | 0.80 | NPC1 (0.49) | HRH3 | |
| SCHEMBL286837 | 0.80 | KCNJ1 (0.73) | KCNJ1KCNH2HRH3SIGMAR1HTR2A | |
| SCHEMBL16868790 | 0.78 | KCNJ1 (0.63) | KCNJ1KCNH2HRH3SIGMAR1HTR2A | |
| SCHEMBL27853032 | 0.78 | KCNJ1 (0.70) | KCNJ1KCNH2HRH3SIGMAR1HTR2A | |
| SCHEMBL2733183 | 0.77 | KCNJ1 (1.00) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL300436 | 0.77 | KCNJ1 (0.73) | KCNJ1KCNH2HRH3SIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129379-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |