Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | OTC | P00480 | 1/20 | 0.40 |
| ▸ | NPY4R | P50391 | 4/20 | 0.40 |
| ▸ | NPY1R | P25929 | 3/20 | 0.40 |
| ▸ | NPY2R | P49146 | 2/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.40 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 2/20 | 0.38 |
| ▸ | FNTB | P49356 | 2/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL1766047 | 0.92 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL15194117 | 0.92 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL9234547 | 0.92 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL13684847 | 0.92 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL1766048 | 0.92 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL27597219 | 0.91 | OTC (0.43) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL306126 | 0.91 | SLC7A5 (0.55) | SLC7A5OTCNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL7555777 | 0.91 | SLC7A5 (0.55) | SLC7A5OTCNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL11595525 | 0.91 | SLC7A5 (0.55) | SLC7A5OTCNPY4RNPY1RNPY2R | |
| Arginine SCHEMBL22116598 | 0.91 | SLC7A5 (0.55) | SLC7A5OTCNPY4RNPY1RNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114146186-B | Polypeptide drug conjugate based on sulfonium salt stabilized target HDAC and application thereof | 华中科技大学同济医学院附属协和医院 | 2023-05-12 | — | — | CN | claimed |
| CN-114146186-A | Sulfonium salt stabilization based HDAC (HDAC) -targeted polypeptide drug conjugate and application thereof | 华中科技大学同济医学院附属协和医院 | 2022-03-08 | — | — | CN | claimed |
| CN-114146186-B | Polypeptide drug conjugate based on sulfonium salt stabilized target HDAC and application thereof | 华中科技大学同济医学院附属协和医院 | 2023-05-12 | — | — | CN | disclosed |
| CN-114146186-A | Sulfonium salt stabilization based HDAC (HDAC) -targeted polypeptide drug conjugate and application thereof | 华中科技大学同济医学院附属协和医院 | 2022-03-08 | — | — | CN | disclosed |