Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2870458 | 0.86 | JAK2 (0.70) | JAK2 | |
| SCHEMBL2862231 | 0.85 | JAK2 (0.59) | JAK2 | |
| SCHEMBL2861618 | 0.83 | JAK2 (0.54) | JAK2CHEK1 | |
| SCHEMBL2861980 | 0.83 | JAK2 (0.73) | JAK2CHEK1 | |
| SCHEMBL3502566 | 0.83 | JAK2 (0.73) | JAK2CHEK1 | |
| SCHEMBL2862232 | 0.82 | JAK2 (0.73) | JAK2CHEK1 | |
| SCHEMBL2879205 | 0.79 | JAK2 (0.75) | JAK2CHEK1 | |
| SCHEMBL2868937 | 0.77 | JAK2 (0.69) | JAK2CHEK1 | |
| SCHEMBL2870510 | 0.76 | JAK2 (0.53) | JAK2 | |
| SCHEMBL13249150 | 0.76 | JAK2 (0.71) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200612-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009035575-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2009-03-19 | — | — | WO | disclosed |