Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.62 |
| ▸ | TYK2 | P29597 | 16/20 | 0.62 |
| ▸ | JAK1 | P23458 | 12/20 | 0.62 |
| ▸ | STAT3 | P40763 | 11/20 | 0.62 |
| ▸ | JAK3 | P52333 | 11/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.58 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29425714 | 1.00 | JAK2 (0.62) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL29232075 | 0.87 | JAK2 (0.58) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL30258437 | 0.87 | JAK2 (0.58) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL29425736 | 0.85 | JAK2 (0.53) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL28706987 | 0.85 | JAK2 (0.53) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL29232102 | 0.82 | JAK2 (0.60) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL29232088 | 0.81 | JAK2 (0.58) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL30291208 | 0.75 | FFAR1 (0.44) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL30258661 | 0.74 | JAK2 (0.39) | JAK2TYK2JAK1STAT3JAK3 | |
| SCHEMBL29232076 | 0.74 | JAK2 (0.39) | JAK2TYK2JAK1STAT3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118159528-A | Pyrazole compounds that inhibit Janus kinase and uses thereof | 爱瑞制药公司 | 2024-06-07 | — | — | CN | disclosed |
| CN-114181199-A | 2, 4-disubstituted pyrimidine derivative and preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2022-03-15 | — | — | CN | disclosed |