Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.57 |
| ▸ | BRD4 | O60885 | 3/20 | 0.56 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.56 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.56 |
| ▸ | IL1B | P01584 | 1/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.56 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28907406 | 0.95 | CRBN (0.55) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL28907397 | 0.91 | CRBN (0.54) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL13584375 | 0.89 | CRBN (0.63) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL28612530 | 0.88 | CRBN (0.60) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL26321010 | 0.88 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL26321021 | 0.88 | CRBN (0.64) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL19438857 | 0.88 | CRBN (0.55) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL19438825 | 0.88 | CRBN (0.55) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL20913661 | 0.88 | CRBN (0.55) | CRBNBRD4IKZF1IKZF3TNF | |
| SCHEMBL30577345 | 0.88 | CRBN (0.55) | CRBNBRD4IKZF1IKZF3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110204543-B | Pyrrolopyridinone bifunctional molecular compound based on Cereblon ligand induced BET degradation | 江苏省中医药研究院 | 2022-03-29 | — | — | CN | disclosed |