SCHEMBL28718306

SCHEMBL28718306

Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(N)c(C#N)c3c2=O)c2scc(C(=O)OC(C)(C)C)c2n1

nearest known ligand 0.84

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29661954 1.00 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL22866523 0.94 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL29560206 0.94 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL22866774 0.94 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL29560096 0.94 EIF4EBP1 (0.84) EIF4EBP1
SCHEMBL22866702 0.93 EIF4EBP1 (0.75) EIF4EBP1
SCHEMBL29661940 0.93 EIF4EBP1 (0.75) EIF4EBP1
SCHEMBL22866710 0.91 EIF4EBP1 (0.85) EIF4EBP1
SCHEMBL29559921 0.91 EIF4EBP1 (0.85) EIF4EBP1
SCHEMBL29661915 0.91 EIF4EBP1 (0.85) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114269756-B 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E 效应疗法股份有限公司 2024-05-14 — — CN disclosed
CN-114269756-A 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E 效应疗法股份有限公司 2022-04-01 — — CN disclosed
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